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Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors

The tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of the matrix metalloproteinases (MMPs). Since unregulated MMP activities are linked to arthritis, cancer, and atherosclerosis, TIMP variants that are selective inhibitors of disease-related MMPs have potential therapeutic...

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Autors principals: Hamze, Asmaa B., Wei, Shuo, Bahudhanapati, Harinath, Kota, Smitha, Acharya, K. Ravi, Brew, Keith
Format: Artigo
Idioma:Inglês
Publicat: Wiley-Blackwell 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206984/
https://ncbi.nlm.nih.gov/pubmed/17660250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072978507
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