DISRUPTION OF THE PACAP GENE PROMOTES MEDULLOBLASTOMA IN PTC1 MUTANT MICE

Hedgehog (Hh) proteins and cAMP-dependent protein kinase A (PKA) generally play opposing roles in developmental patterning events. Humans and mice heterozygous for mutations in the Sonic hedgehog (Shh) receptor gene patched-1 (ptc1) have an increased incidence of certain types of cancer, including m...

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Detalhes bibliográficos
Main Authors: Lelievre, Vincent, Seksenyan, Akop, Nobuta, Hiroko, Yong, William H., Chhith, Seririthanar, Niewiadomski, Pawel, Cohen, Joseph R., Dong, Hongmei, Flores, Avegail, Liau, Linda M., Kornblum, Harley I., Scott, Matthew P., Waschek, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206628/
https://ncbi.nlm.nih.gov/pubmed/18036580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2007.10.031
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