ICA512 signaling enhances pancreatic β-cell proliferation by regulating cyclins D through STATs

Changes in metabolic demands dynamically regulate the total mass of adult pancreatic β-cells to adjust insulin secretion and preserve glucose homeostasis. Glucose itself is a major regulator of β-cell proliferation by inducing insulin secretion and activating β-cell insulin receptors. Here, we show...

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Detalhes bibliográficos
Main Authors: Mziaut, Hassan, Kersting, Stephan, Knoch, Klaus-Peter, Fan, Wan-Hung, Trajkovski, Mirko, Erdmann, Katja, Bergert, Hendrik, Ehehalt, Florian, Saeger, Hans-Detlev, Solimena, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206595/
https://ncbi.nlm.nih.gov/pubmed/18178618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710931105
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