Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

c-myc is essential for cell homeostasis and growth but lethal if improperly regulated. Transcription of this oncogene is governed by the counterbalancing forces of two proteins on TFIIH—the FUSE binding protein (FBP) and the FBP-interacting repressor (FIR). FBP and FIR recognize single-stranded DNA...

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Autori principali: Crichlow, Gregg V, Zhou, Hongwen, Hsiao, Hsin-hao, Frederick, Kendra B, Debrosse, Maxime, Yang, Yuande, Folta-Stogniew, Ewa J, Chung, Hye-Jung, Fan, Chengpeng, De La Cruz, Enrique M, Levens, David, Lolis, Elias, Braddock, Demetrios
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206118/
https://ncbi.nlm.nih.gov/pubmed/18059478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601936
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