Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

c-myc is essential for cell homeostasis and growth but lethal if improperly regulated. Transcription of this oncogene is governed by the counterbalancing forces of two proteins on TFIIH—the FUSE binding protein (FBP) and the FBP-interacting repressor (FIR). FBP and FIR recognize single-stranded DNA...

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Main Authors: Crichlow, Gregg V, Zhou, Hongwen, Hsiao, Hsin-hao, Frederick, Kendra B, Debrosse, Maxime, Yang, Yuande, Folta-Stogniew, Ewa J, Chung, Hye-Jung, Fan, Chengpeng, De La Cruz, Enrique M, Levens, David, Lolis, Elias, Braddock, Demetrios
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206118/
https://ncbi.nlm.nih.gov/pubmed/18059478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601936
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