Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

c-myc is essential for cell homeostasis and growth but lethal if improperly regulated. Transcription of this oncogene is governed by the counterbalancing forces of two proteins on TFIIH—the FUSE binding protein (FBP) and the FBP-interacting repressor (FIR). FBP and FIR recognize single-stranded DNA...

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Bibliografski detalji
Glavni autori: Crichlow, Gregg V, Zhou, Hongwen, Hsiao, Hsin-hao, Frederick, Kendra B, Debrosse, Maxime, Yang, Yuande, Folta-Stogniew, Ewa J, Chung, Hye-Jung, Fan, Chengpeng, De La Cruz, Enrique M, Levens, David, Lolis, Elias, Braddock, Demetrios
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206118/
https://ncbi.nlm.nih.gov/pubmed/18059478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601936
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