Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition

c-myc is essential for cell homeostasis and growth but lethal if improperly regulated. Transcription of this oncogene is governed by the counterbalancing forces of two proteins on TFIIH—the FUSE binding protein (FBP) and the FBP-interacting repressor (FIR). FBP and FIR recognize single-stranded DNA...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Crichlow, Gregg V, Zhou, Hongwen, Hsiao, Hsin-hao, Frederick, Kendra B, Debrosse, Maxime, Yang, Yuande, Folta-Stogniew, Ewa J, Chung, Hye-Jung, Fan, Chengpeng, De La Cruz, Enrique M, Levens, David, Lolis, Elias, Braddock, Demetrios
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206118/
https://ncbi.nlm.nih.gov/pubmed/18059478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601936
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak