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Optimal design and validation of antiviral siRNA for targeting HIV-1

We propose rational designing of antiviral short-interfering RNA (siRNA) targeting highly divergent HIV-1. In this study, conserved regions within HIV-1 genomes were identified through an exhaustive computational analysis, and the functionality of siRNAs targeting the highest possible conserved regi...

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Hlavní autoři: Naito, Yuki, Nohtomi, Kyoko, Onogi, Toshinari, Uenishi, Rie, Ui-Tei, Kumiko, Saigo, Kaoru, Takebe, Yutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2204037/
https://ncbi.nlm.nih.gov/pubmed/17996047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-4-80
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