Therapeutic T cells induce tumor-directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines

BACKGROUND: The mechanisms by which tumor-specific T cells induce regression of established metastases are not fully characterized. In using the poorly immunogenic B16BL6-D5 (D5) melanoma model we reported that T cell-mediated tumor regression can occur independently of perforin, IFN-γ or the combin...

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Main Authors: Winter, Hauke, van den Engel, Natasja K, Rüttinger, Dominik, Schmidt, Jürgen, Schiller, Matthias, Poehlein, Christian H, Löhe, Florian, Fox, Bernard A, Jauch, Karl-Walter, Hatz, Rudolf A, Hu, Hong-Ming
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203985/
https://ncbi.nlm.nih.gov/pubmed/18001476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-5-56
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