Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome

BACKGROUND: Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations coupled with coulometric array detection that can accurately identify ad libitum...

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Main Authors: Shurubor, Yevgeniya I, Matson, Wayne R, Willett, Walter C, Hankinson, Susan E, Kristal, Bruce S
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203971/
https://ncbi.nlm.nih.gov/pubmed/17997839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6890-7-9
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