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Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3
The E3 ubiquitin ligase neuregulin receptor degrading protein 1 (Nrdp1) mediates the ligand-independent degradation of the epidermal growth factor receptor family member ErbB3/HER3. By regulating cellular levels of ErbB3, Nrdp1 influences ErbB3-mediated signaling, which is essential for normal verte...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2203331/ https://ncbi.nlm.nih.gov/pubmed/17384230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062700307 |
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