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Dynamic Requirements for a Functional Protein Hinge
The enzyme triosephosphate isomerase (TIM) is a model of catalytic efficiency. The 11-residue loop 6 at the TIM active site plays a major role in this enzymatic prowess. The loop moves between open and closed states, which facilitate substrate access and catalysis, respectively. The N- and C-termina...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2203303/ https://ncbi.nlm.nih.gov/pubmed/17336327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.01.074 |
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