Pharmacokinetic interaction between TMC114/ritonavir and tenofovir disoproxil fumarate in healthy volunteers

AIM: TMC114 is a new HIV protease inhibitor, used in combination with low-dose ritonavir (TMC114/r) as a pharmacokinetic enhancer. Tenofovir disoproxil fumarate (TDF) is a nucleotide reverse transcriptase inhibitor. Both antiretrovirals show activity against wild-type and resistant HIV. An open-labe...

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Autori principali: Hoetelmans, Richard M W, Mariën, Kris, De Pauw, Martine, Hill, Andrew, Peeters, Monika, Sekar, Vanitha, De Doncker, Piet, Woodfall, Brian, Lefebvre, Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2007
Soggetti:
Drug Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203266/
https://ncbi.nlm.nih.gov/pubmed/17610528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02957.x
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