Pharmacokinetic modelling of the placental transfer of nelfinavir and its M8 metabolite: a population study using 75 maternal-cord plasma samples

AIMS: A population pharmacokinetic model was developed to characterize the transfer of nelfinavir and its active metabolite M8 from maternal to cord plasma and amniotic fluid. METHODS: Concentration data were obtained from 75 women on the day of delivery and for whom maternal, umbilical plasma and a...

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Detalhes bibliográficos
Main Authors: Hirt, Déborah, Urien, Saïk, Jullien, Vincent, Firtion, Ghislaine, Chappuy, Hélène, Rey, Elisabeth, Pons, Gérard, Mandelbrot, Laurent, Treluyer, Jean-Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Pharmacokinetics and Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203265/
https://ncbi.nlm.nih.gov/pubmed/17892516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02885.x
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