Relationship between 5-fluorouracil exposure and outcome in patients receiving continuous venous infusion with or without concomitant radiotherapy

AIMS: Toxicity and response are correlated with plasma 5-fluorouracil (5-FU) concentration in patients treated with 5-FU at a dose of 1000 mg m(−2) day(−1). Head and neck cancer patients are treated with various therapeutic regimens, including chemotherapy with 5-FU at a dose of 600 mg m(−2) day(−1)...

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Main Authors: Beneton, Maud, Chapet, Sophie, Blasco, Hélène, Giraudeau, Bruno, Boisdron-Celle, Michèle, Deporte-Fety, Régine, Denis, Fabrice, Narcisso, Bérangère, Calais, Gilles, Le Guellec, Chantal
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2007
Assuntos:
Pharmacokinetics and Pharmacodynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203258/
https://ncbi.nlm.nih.gov/pubmed/17578483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02951.x
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