Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

The Notch family of proteins consists of transmembrane receptors that play a critical role in the determination of cell fate. Genetic studies in Caenorhabditis elegans suggest that the presenilin proteins, which are associated with familial Alzheimer’s disease, regulate Notch signaling. Here we show...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Song, Weihong, Nadeau, Philip, Yuan, Menglan, Yang, Xudong, Shen, Jie, Yankner, Bruce A.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC22024/
https://ncbi.nlm.nih.gov/pubmed/10359821
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki