Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

The Notch family of proteins consists of transmembrane receptors that play a critical role in the determination of cell fate. Genetic studies in Caenorhabditis elegans suggest that the presenilin proteins, which are associated with familial Alzheimer’s disease, regulate Notch signaling. Here we show...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Song, Weihong, Nadeau, Philip, Yuan, Menglan, Yang, Xudong, Shen, Jie, Yankner, Bruce A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6959
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