Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

The Notch family of proteins consists of transmembrane receptors that play a critical role in the determination of cell fate. Genetic studies in Caenorhabditis elegans suggest that the presenilin proteins, which are associated with familial Alzheimer’s disease, regulate Notch signaling. Here we show...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Song, Weihong, Nadeau, Philip, Yuan, Menglan, Yang, Xudong, Shen, Jie, Yankner, Bruce A.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1999
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22024/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359821/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6959
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