The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

The protein kinase Akt/PKB is a crucial regulator of cell survival in response to mitogenic signals. The increased kinase activity of v-akt, an oncogenic form of Akt/PKB, causes mouse T cell lymphoma, and overexpression of Akt/PKB is associated with progression of several tumor types in human. In th...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Li, Hsiu-Ling, Davis, William W., Whiteman, Eileen L., Birnbaum, Morris J., Puré, Ellen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6890
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