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The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes

The protein kinase Akt/PKB is a crucial regulator of cell survival in response to mitogenic signals. The increased kinase activity of v-akt, an oncogenic form of Akt/PKB, causes mouse T cell lymphoma, and overexpression of Akt/PKB is associated with progression of several tumor types in human. In th...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Li, Hsiu-Ling, Davis, William W., Whiteman, Eileen L., Birnbaum, Morris J., Puré, Ellen
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22012/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359809/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6890
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