IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells have been implicated in the lack of effective antitumor immunity. Denileukin diftitox (DAB(389)IL-2), a fusion protein of interleukin 2 (IL-2) and diphtheria toxin, provides a means of targeting Treg cells. In this study, we examined (1) the effect of...

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Main Authors: Litzinger, Mary T., Fernando, Romaine, Curiel, Tyler J., Grosenbach, Douglas W., Schlom, Jeffrey, Palena, Claudia
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2007
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200901/
https://ncbi.nlm.nih.gov/pubmed/17616639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094615
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