A(2A) receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells

Tissue-derived adenosine, acting via the adenosine A(2A) receptor (A(2A)R), is emerging as an important negative regulator of T-cell function. In this report, we demonstrate that A(2A)R stimulation not only inhibits the generation of adaptive effector T cells but also promotes the induction of adapt...

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Detalhes bibliográficos
Main Authors: Zarek, Paul E., Huang, Ching-Tai, Lutz, Eric R., Kowalski, Jeanne, Horton, Maureen R., Linden, Joel, Drake, Charles G., Powell, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200810/
https://ncbi.nlm.nih.gov/pubmed/17909080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-081646
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