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IL-21–mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8(+) cytotoxic T lymphocytes
Efforts to reproducibly isolate tumor antigen–specific T cells from patients would be facilitated by removing immunoregulatory barriers. Using a human model for eliciting T-cell responses to tumor-associated antigens, we develop a novel strategy that eliminates nearly all Foxp3-expressing cells thro...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society of Hematology
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200808/ https://ncbi.nlm.nih.gov/pubmed/17921346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-089375 |
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