A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans

It is traditionally held that human IgG4 MoAbs should not deplete target cells in vivo, as this isotype is inactive in a number of in vitro assays that measure effector function. We have previously challenged this dogma, and the current study was designed to investigate the in vivo biological effect...

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Autors principals: ISAACS, J D, WING, M G, GREENWOOD, J D, HAZLEMAN, B L, HALE, G, WALDMANN, H
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1996
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200623/
https://ncbi.nlm.nih.gov/pubmed/8973608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1996.d01-876.x
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