Susceptibility to clinically manifest cyclosporine A (CsA)-induced autoimmune disease is associated with interferon-gamma (IFN-γ)-producing CD45RC(+)RT6(−) T helper cells

Lethally irradiated Lewis (LEW) rats reconstituted with syngeneic bone marrow and given CsA for a 4-week period, develop, upon withdrawal of CsA, a graft-versus-host-like disease, so-called CsA-induced autoimmunity (CsA-AI). This T cell-mediated autoimmune disease is thymus-dependent; it is generall...

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Autores principales: BEIJLEVELD, L J J, GROEN, H, BROEREN, C P M, KLATTER, F A, KAMPINGA, J, DAMOISEAUX, J G M C, VAN BREDA VRIESMAN, P J C
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 1996
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200537/
https://ncbi.nlm.nih.gov/pubmed/8809139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1996.d01-797.x
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