Defective de novo thymocyte maturation in cyclosporin A (CsA)-induced autoimmunity: expression of costimulatory and activation molecules

Lethally x-irradiated Lewis rats, reconstituted with syngeneic bone marrow and transiently treated with CsA for 4 weeks, will develop an autoimmune disease about 2–3 weeks after cessation of CsA therapy. CsA-induced autoimmunity is a thymus-dependent and T cell-mediated autoimmune disease. CsA is th...

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Detalhes bibliográficos
Main Authors: HOMMA, M, VAN BREDA VRIESMAN, P J C, DAMOISEAUX, J G M C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1997
Assuntos:
Editorial Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904792/
https://ncbi.nlm.nih.gov/pubmed/9353152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1997.5001397.x
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