An experimental solution for the Luria–Delbrück fluctuation problem in measuring hypermutation rates

A cell line harboring all trans-acting elements necessary for hypermutation was transfected with a plasmid harboring the major cis-acting elements plus a green fluorescent protein gene containing a premature chain-termination codon. Transfected cells do not fluoresce unless the stop codon reverts. W...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Bachl, Jürgen, Dessing, Mark, Olsson, Carina, von Borstel, R. C., Steinberg, Charles
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1999
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22004/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359801/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6847
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