The Ndc80p Complex from Saccharomyces cerevisiae Contains Conserved Centromere Components and Has a Function in Chromosome Segregation

We have purified a complex from Saccharomyces cerevisiae containing the spindle components Ndc80p, Nuf2p, Spc25p, and Spc24p. Temperature-sensitive mutants in NDC80, SPC25, and SPC24 show defects in chromosome segregation. In spc24-1 cells, green fluorescence protein (GFP)-labeled centromeres fail t...

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Main Authors: Wigge, Philip A., Kilmartin, John V.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2001
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199619/
https://ncbi.nlm.nih.gov/pubmed/11266451
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