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A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation

Tissue-remodeling processes are largely mediated by members of the matrix metalloproteinase (MMP) family of endopeptidases whose expression is strictly controlled both spatially and temporally. In this article, we have examined the molecular mechanisms that could contribute to modulate the expressio...

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Detalhes bibliográficos
Main Authors: Jiménez, Maria J.G., Balbín, Milagros, Alvarez, Jesús, Komori, Toshihisa, Bianco, Paolo, Holmbeck, Kenn, Birkedal-Hansen, Henning, López, José M., López-Otín, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199331/
https://ncbi.nlm.nih.gov/pubmed/11748248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200106147
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