In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

Granzyme (gzm) A and gzmB have been implicated in Fas-independent nucleolytic and cytolytic processes exerted by cytotoxic T (Tc) cells, but the underlying mechanism(s) remains unclear. In this study, we compare the potential of Tc and natural killer (NK) cells of mice deficient in both gzmA and B (...

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Bibliographic Details
Main Authors: Simon, Markus M., Hausmann, Michael, Tran, Thao, Ebnet, Klaus, Tschopp, Jürg, ThaHla, Ron, Müllbacher, Arno
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1997
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Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199142/
https://ncbi.nlm.nih.gov/pubmed/9362539
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