A Small-molecule Inhibitor Directed against the Chemokine Receptor CXCR4 Prevents its Use as an HIV-1 Coreceptor

The chemokine receptor CXCR4 is the major coreceptor used for cellular entry by T cell– tropic human immunodeficiency virus (HIV)-1 strains, whereas CCR5 is used by macrophage (M)-tropic strains. Here we show that a small-molecule inhibitor, ALX40-4C, inhibits HIV-1 envelope (Env)-mediated membrane...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Doranz, Benjamin J., Grovit-Ferbas, Kathie, Sharron, Matthew P., Mao, Si-Hua, Goetz, Matthew Bidwell, Daar, Eric S., Doms, Robert W., O'Brien, William A.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 1997
Предметы:
Brief Definitive Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199097/
https://ncbi.nlm.nih.gov/pubmed/9334380
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы