Impaired Plasma Membrane Targeting of Grb2–Murine Son of Sevenless (mSOS) Complex and Differential Activation of the Fyn–T Cell Receptor (TCR)-ζ–Cbl Pathway Mediate T Cell Hyporesponsiveness in Autoimmune Nonobese Diabetic Mice

Nonobese diabetic (NOD) mouse thymocytes are hyporesponsive to T cell antigen receptor (TCR)-mediated stimulation of proliferation, and this T cell hyporesponsiveness may be causal to the onset of autoimmune diabetes in NOD mice. We previously showed that TCR-induced NOD T cell hyporesponsiveness is...

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Hlavní autoři: Salojin, Konstantin, Zhang, Jian, Cameron, Mark, Gill, Bruce, Arreaza, Guillermo, Ochi, Atsuo, Delovitch, Terry L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 1997
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199053/
https://ncbi.nlm.nih.gov/pubmed/9294143
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