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Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8(+) T Cells

In this report, we show that cross-presentation of self-antigens can lead to the peripheral deletion of autoreactive CD8(+) T cells. We had previously shown that transfer of ovalbumin (OVA)-specific CD8(+) T cells (OT-I cells) into rat insulin promoter–membrane-bound form of OVA transgenic mice, whi...

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Autori principali: Kurts, Christian, Kosaka, Hiroshi, Carbone, Francis R., Miller, Jacques F.A.P., Heath, William R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2198972/
https://ncbi.nlm.nih.gov/pubmed/9221753
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