4-1BB Costimulatory Signals Preferentially Induce CD8(+) T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4(+) and CD8(+) T cells after antigen- or mitogen-induced activation. Cross-linking of 4-1BB and the T cell receptor (TCR) on a...

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Main Authors: Shuford, Walter W., Klussman, Kerry, Tritchler, Douglas D., Loo, Deryk T., Chalupny, Jan, Siadak, Anthony W., Brown, T. Joseph, Emswiler, John, Raecho, Hong, Larsen, Christian P., Pearson, Thomas C., Ledbetter, Jeffrey A., Aruffo, Alejandro, Mittler, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2198949/
https://ncbi.nlm.nih.gov/pubmed/9206996
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