Lymphotoxin-α (LTα) Supports Development of Splenic Follicular Structure That Is Required for IgG Responses

LTα-deficient (LTα(−/−)) mice show altered splenic microarchitecture. This includes loss of normal B cell–T cell compartmentalization, of follicular dendritic cell (FDC) clusters, and of ability to form germinal centers (GC). LTα(−/−) mice immunized with sheep red blood cells (SRBC) produced high le...

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Hauptverfasser: Fu, Yang-Xin, Molina, Hector, Matsumoto, Mitsuru, Huang, Guangming, Min, Jingjuan, Chaplin, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1997
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196348/
https://ncbi.nlm.nih.gov/pubmed/9182683
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