Mutants in the ADP-ribosyltransferase Cleft of Cholera Toxin Lack Diarrheagenicity but Retain Adjuvanticity

Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent diarrhea-inducing properties. We have constructed two CT-A subunit mutants, e.g., serine→ phenylalanine at position 61 (S61F), and glutamic acid→ lysine at 112 (E112K) by s...

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Main Authors: Yamamoto, Shingo, Takeda, Yoshifumi, Yamamoto, Masafumi, Kurazono, Hisao, Imaoka, Koichi, Yamamoto, Miho, Fujihashi, Kohtaro, Noda, Masatoshi, Kiyono, Hiroshi, McGhee, Jerry R.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1997
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196267/
https://ncbi.nlm.nih.gov/pubmed/9104807
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