UPREGULATION OF BNIP3 AND TRANSLOCATION TO MITOCHONDRIA MEDIATES CYANIDE-INDUCED APOPTOSIS IN CORTICAL CELLS

BNIP3, a BH3 domain only Bcl-2 protein, has been identified as a mitochrondrial mediator of hypoxia-induced cell death. Since cyanide produces histotoxic anoxia (chemical hypoxia), the present study was undertaken in primary cortical cells to determine involvement of the BNIP3 signaling pathway in c...

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Autores principales: Prabhakaran, K., Li, L., Zhang, L., Borowitz, J.L., Isom, G.E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196214/
https://ncbi.nlm.nih.gov/pubmed/17980495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.07.033
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