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Uncoupling Protein-2 Up-regulation and Enhanced Cyanide Toxicity are Mediated by PPARα Activation and Oxidative Stress
Uncoupling protein 2 (UCP-2) is an inner mitochondrial membrane proton carrier that modulates mitochondrial membrane potential (ΔΨm) and uncouples oxidative phosphorylation. We have shown that up-regulation of UCP-2 by Wy14,643, a selective peroxisome proliferator-activated receptor-α (PPARα) agonis...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1994772/ https://ncbi.nlm.nih.gov/pubmed/17573087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2007.05.002 |
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