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Physiological regulation of β-catenin stability by Tcf3 and CK1ε
The wnt pathway regulates the steady state level of β-catenin, a transcriptional coactivator for the Tcf3/Lef1 family of DNA binding proteins. We demonstrate that Tcf3 can inhibit β-catenin turnover via its competition with axin and adenomatous polyposis for β-catenin binding. A mutant of β-catenin...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2001
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2196183/ https://ncbi.nlm.nih.gov/pubmed/11524435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200102074 |
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