Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

To explore the role of the interleukin (IL)-1β converting enzyme (ICE) in neuronal apoptosis, we designed a mutant ICE gene (C285G) that acts as a dominant negative ICE inhibitor. Microinjection of the mutant ICE gene into embryonal chicken dorsal root ganglial neurons inhibits trophic factor withdr...

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Hauptverfasser: Friedlander, Robert M., Gagliardini, Valeria, Hara, Hideaki, Fink, Klaus B., Li, Weiwei, MacDonald, Glen, Fishman, Mark C., Greenberg, Arnold H., Moskowitz, Michael A., Yuan, Junying
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1997
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196165/
https://ncbi.nlm.nih.gov/pubmed/9120399
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