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Sustained Activation of Lyn Tyrosine Kinase In Vivo Leads to Autoimmunity
Genetic ablation of the Lyn tyrosine kinase has revealed unique inhibitory roles in B lymphocyte signaling. We now report the consequences of sustained activation of Lyn in vivo using a targeted gain-of-function mutation (Lyn(up/up) mice). Lyn(up/up) mice have reduced numbers of conventional B lymph...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2196073/ https://ncbi.nlm.nih.gov/pubmed/12486102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020515 |
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