Plasmodium falciparum Phospholipase C Hydrolyzing Sphingomyelin and Lysocholinephospholipids Is a Possible Target for Malaria Chemotherapy

Sphingomyelinase (SMase) is one of the principal enzymes in sphingomyelin (SM) metabolism. Here, we identified a Plasmodium falciparum gene (PfNSM) encoding a 46-kD protein, the amino acid sequence of which is ∼25% identical to that of bacteria SMases. Biochemical analyses of the recombinant protein...

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Main Authors: Hanada, Kentaro, Palacpac, Nirianne Marie Q., Magistrado, Pamela A., Kurokawa, Ken, Rai, Ganesh, Sakata, Daiji, Hara, Tomoko, Horii, Toshihiro, Nishijima, Masahiro, Mitamura, Toshihide
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196011/
https://ncbi.nlm.nih.gov/pubmed/11781362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20010724
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