Resistance to Granzyme B-mediated Cytochrome c Release in Bak-deficient Cells

Granzyme B (GrB), a serine protease with substrate specificity similar to the caspase family, is a major component of granule-mediated cytotoxicity of T lymphocytes. Although GrB can directly activate caspases, it induces apoptosis predominantly via Bid cleavage, mitochondrial outer membrane permeab...

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Detalhes bibliográficos
Main Authors: Wang, Gui-Qiang, Wieckowski, Eva, Goldstein, Leslie A., Gastman, Brian R., Rabinovitz, Asaf, Gambotto, Andrea, Li, Shuchen, Fang, Bingliang, Yin, Xiao-Ming, Rabinowich, Hannah
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195982/
https://ncbi.nlm.nih.gov/pubmed/11696597
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