Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses

The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263–272, KRWIILGLNK). Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264...

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Autors principals: Kelleher, Anthony D., Long, Chad, Holmes, Edward C., Allen, Rachel L., Wilson, Jamie, Conlon, Christopher, Workman, Cassy, Shaunak, Sunil, Olson, Kara, Goulder, Philip, Brander, Christian, Ogg, Graham, Sullivan, John S., Dyer, Wayne, Jones, Ian, McMichael, Andrew J., Rowland-Jones, Sarah, Phillips, Rodney E.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2001
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195921/
https://ncbi.nlm.nih.gov/pubmed/11157057
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