Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses

The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263–272, KRWIILGLNK). Substitution of lysine (K) or glycine (G) for arginine (R) at HIV-1 gag residue 264 (R264...

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Bibliographic Details
Main Authors: Kelleher, Anthony D., Long, Chad, Holmes, Edward C., Allen, Rachel L., Wilson, Jamie, Conlon, Christopher, Workman, Cassy, Shaunak, Sunil, Olson, Kara, Goulder, Philip, Brander, Christian, Ogg, Graham, Sullivan, John S., Dyer, Wayne, Jones, Ian, McMichael, Andrew J., Rowland-Jones, Sarah, Phillips, Rodney E.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195921/
https://ncbi.nlm.nih.gov/pubmed/11157057
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