B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β

The B cell receptor (BCR) regulates B cell development and function through immunoglobulin (Ig)α and Igβ, a pair of membrane-bound Ig superfamily proteins, each of which contains a single cytoplasmic immunoreceptor tyrosine activation motif (ITAM). To determine the function of Igβ, we produced mice...

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Bibliographic Details
Main Authors: Reichlin, Amy, Hu, Yun, Meffre, Eric, Nagaoka, Hitoshi, Gong, Shiaoching, Kraus, Manfred, Rajewsky, Klaus, Nussenzweig, Michel C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195879/
https://ncbi.nlm.nih.gov/pubmed/11136817
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