Interference with Immunoglobulin (Ig)α Immunoreceptor Tyrosine–Based Activation Motif (Itam) Phosphorylation Modulates or Blocks B Cell Development, Depending on the Availability of an Igβ Cytoplasmic Tail

To determine the function of immunoglobulin (Ig)α immunoreceptor tyrosine–based activation motif (ITAM) phosphorylation, we generated mice in which Igα ITAM tyrosines were replaced by phenylalanines (Igα(FF/FF)). Igα(FF/FF)mice had a specific reduction of B1 and marginal zone B cells, whereas B2 cel...

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Detalhes bibliográficos
Main Authors: Kraus, Manfred, Pao, Lily I., Reichlin, Amy, Hu, Yun, Canono, Beth, Cambier, John C., Nussenzweig, Michel C., Rajewsky, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193498/
https://ncbi.nlm.nih.gov/pubmed/11514602
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