Defective Granule Exocytosis in Rab27a-Deficient Lymphocytes from Ashen Mice

Because mutations in Rab27a have been linked to immune defects in humans, we have examined cytotoxic lymphocyte function in ashen mice, which contain a splicing mutation in Rab27a. Ashen cytotoxic T lymphocytes (CTLs) showed a >90% reduction in lytic activity on Fas-negative target cells compared...

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Main Authors: Haddad, Elias K., Wu, Xufeng, Hammer, John A., Henkart, Pierre A.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195776/
https://ncbi.nlm.nih.gov/pubmed/11266473
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