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An Essential Role for the Substrate-Binding Region of Hsp40s in Saccharomyces cerevisiae

In addition to regulating the ATPase cycle of Hsp70, a second critical role of Hsp40s has been proposed based on in vitro studies: binding to denatured protein substrates, followed by their presentation to Hsp70 for folding. However, the biological importance of this model is challenged by the fact...

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Detalles Bibliográficos
Main Authors: Johnson, Jill L., Craig, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195774/
https://ncbi.nlm.nih.gov/pubmed/11266475
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