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RNA cleaving ‘10-23’ DNAzymes with enhanced stability and activity
‘10-23’ DNAzymes can be used to cleave any target RNA in a sequence-specific manner. For applications in vivo, they have to be stabilised against nucleolytic attack by the introduction of modified nucleotides without obstructing cleavage activity. In this study, we optimise the design of a DNAzyme t...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC219472/ https://ncbi.nlm.nih.gov/pubmed/14530446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg791 |
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