Targeted Inactivation of the IL-4 Receptor α Chain I4R Motif Promotes Allergic Airway Inflammation

The insulin/interleukin-4 (IL-4) receptor (I4R) motif mediates the association of insulin receptor substrate (IRS)-2 with the interleukin-4 (IL-4)Rα chain and transduces mitogenic signals in response to IL-4. Its physiological functions were analyzed in mice with a germline point mutation that chang...

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Main Authors: Blaeser, Frank, Bryce, Paul J., Ho, Nga, Raman, Vidya, Dedeoglu, Fatma, Donaldson, Debra D., Geha, Raif S., Oettgen, Hans C., Chatila, Talal A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194235/
https://ncbi.nlm.nih.gov/pubmed/14557412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030471
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