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Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture
The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a β sheet and a large α-helical insertion. Sequence comparisons suggested that similar activ...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2194165/ https://ncbi.nlm.nih.gov/pubmed/18184589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.10.026 |
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