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Structure of the Human Protein Kinase MPSK1 Reveals an Atypical Activation Loop Architecture

The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a β sheet and a large α-helical insertion. Sequence comparisons suggested that similar activ...

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Detalhes bibliográficos
Main Authors: Eswaran, Jeyanthy, Bernad, Antonio, Ligos, Jose M., Guinea, Barbara, Debreczeni, Judit É., Sobott, Frank, Parker, Sirlester A., Najmanovich, Rafael, Turk, Benjamin E., Knapp, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194165/
https://ncbi.nlm.nih.gov/pubmed/18184589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.10.026
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