The Helicobacter pylori Vacuolating Toxin Inhibits T Cell Activation by Two Independent Mechanisms

Helicobacter pylori toxin, VacA, damages the gastric epithelium by erosion and loosening of tight junctions. Here we report that VacA also interferes with T cell activation by two different mechanisms. Formation of anion-specific channels by VacA prevents calcium influx from the extracellular milieu...

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Detalhes bibliográficos
Main Authors: Boncristiano, Marianna, Paccani, Silvia Rossi, Barone, Silvia, Ulivieri, Cristina, Patrussi, Laura, Ilver, Dag, Amedei, Amedeo, D'Elios, Mario Milco, Telford, John L., Baldari, Cosima T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194151/
https://ncbi.nlm.nih.gov/pubmed/14676300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030621
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