Use of a Small Molecule CCR5 Inhibitor in Macaques to Treat Simian Immunodeficiency Virus Infection or Prevent Simian–Human Immunodeficiency Virus Infection

Human immunodeficiency virus type 1 (HIV-1) fuses with cells after sequential interactions between its envelope glycoproteins, CD4 and a coreceptor, usually CC chemokine receptor 5 (CCR5) or CXC receptor 4 (CXCR4). CMPD 167 is a CCR5-specific small molecule with potent antiviral activity in vitro. W...

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Hlavní autoři: Veazey, Ronald S., Klasse, Per Johan, Ketas, Thomas J., Reeves, Jacqueline D., Piatak, Michael, Kunstman, Kevin, Kuhmann, Shawn E., Marx, Preston A., Lifson, Jeffrey D., Dufour, Jason, Mefford, Megan, Pandrea, Ivona, Wolinsky, Steven M., Doms, Robert W., DeMartino, Julie A., Siciliano, Salvatore J., Lyons, Kathy, Springer, Martin S., Moore, John P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194125/
https://ncbi.nlm.nih.gov/pubmed/14623909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031266
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