Use of a Small Molecule CCR5 Inhibitor in Macaques to Treat Simian Immunodeficiency Virus Infection or Prevent Simian–Human Immunodeficiency Virus Infection

Human immunodeficiency virus type 1 (HIV-1) fuses with cells after sequential interactions between its envelope glycoproteins, CD4 and a coreceptor, usually CC chemokine receptor 5 (CCR5) or CXC receptor 4 (CXCR4). CMPD 167 is a CCR5-specific small molecule with potent antiviral activity in vitro. W...

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Main Authors: Veazey, Ronald S., Klasse, Per Johan, Ketas, Thomas J., Reeves, Jacqueline D., Piatak, Michael, Kunstman, Kevin, Kuhmann, Shawn E., Marx, Preston A., Lifson, Jeffrey D., Dufour, Jason, Mefford, Megan, Pandrea, Ivona, Wolinsky, Steven M., Doms, Robert W., DeMartino, Julie A., Siciliano, Salvatore J., Lyons, Kathy, Springer, Martin S., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194125/
https://ncbi.nlm.nih.gov/pubmed/14623909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031266
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